Includes bibliographical references and index.

Section I Fundamental Principles -- 1. Introduction to clinical research / Gordon H. Williams and David Robertson -- 2. Patient-oriented research / Ellen W. Seely and Steven Grinspoon -- 3. Clinical trials / Robert M. Califf -- 4. Introduction to epidemiology / Donna K. Arnett and Steven A. Claas -- 5. The patient-centered outcomes research institute / Joe V. Selby and Danielle M. Whicher -- 6. Health-care technology assessment (HTA) / Uwe E. Reinhardt -- 7. Health services research / J. Sanford Schwartz -- Section II Approaches -- 8. Measurement of biological materials / Mark D. Kellogg -- 9. Imaging tools in clinical research / Ruth M. Dunne, Alibhe C. O'Neill and Clare M. Tempany -- 10. Imaging tools in human research / Ruth M. Dunne, Alibhe C. O'Neill and Clare M. Tempany -- 11. Nanotechnology in clinical and translational research / James B. Baker Jr., Brent B. Ward and Thommey P. Thomas -- 12. The use of questionnaires and surveys / Marcia A. Testa and Donald C. Simonson -- 13. Informational technology / Shawn N. Murphy, Henry C. Chueh and Christopher D. Herrick -- 14. Principles of biostatistics / Kush Kapur -- 15. Good clinical practice and good laboratory practice / Nathalie K. Zgheib, Stephanie L. Tomasic and Robert A. Branch -- Section III Human Genetics -- Introduction to human genetics / Bruce R. Korf -- 17. Epidemiologic and population genetic studies / Angela J. Rogers and Scott T. Weiss -- 18. Pharmacogenetics of drug metabolism / Zerusenay Desta and David A. Flockhart -- 19. Statistical techniques for genetic analysis / Jessica Lasky-Su -- Section IV Human Pharmacology -- 20. Introduction to clinical pharmacology / Rommel G. Tirona and Richard B. Kim -- 21. Adverse drug events / Dan M. Roden -- Section V Societal Context of Human Research -- 22. Translating science to the bedside / Seema Basu -- 23. Regulatory environment / Christine Nguyen, Audrey Gassman and Hylton V. Joffe -- 24. Ethical issues in translational research and clinical investigation / Greg Koski -- 25. Clinical research in the public eye / Mary Wooley -- Section VI Research in Special Populations -- 26. Research in special populations / Todd W. Rice and Gordon R. Bernard -- 27. Research in the emergency care environment / James Quinn and Daniel J. Pallin -- 28. Psychiatric disorders / Alan F. Schatzberg -- 29. Research in special populations / Stephanie Studenski and Luigi Ferrucci -- 30. Clinical research in neurology / Keren Regev and Howard L. Weiner -- 31. Research in pediatrics / Lisa Bomgaars, Stacey Berg and Ann R. Stark -- 32. Cancer as a paradigm for translational and clinical biomedical research / César Serrano and George D. Demetri -- 33. Maintaining an emphasis on rare diseases with research initiatives and resources at the national center for advancing translational sciences / Stephen C. Groft and Rashmi Gopal-Srivastava -- Section VII Infrastructure -- 34. Clinical and Translational Science Infrastructure / David Robertson and Gordon H. Williams -- Section VIII Education, Training and Career Choices -- 35. Education, Training and Career Choices / Katherine E. Hartmann, Elizabeth Heitman and Nancy J. Brown -- A stepwise approach to a career in translational research / William F. Crowley Jr. -- Physician careers in the pharmaceutical industry / Ronald L. Krall -- Section IX Research in Academia -- 38. Industry-sponsored clinical research in academia / Italo Biaggioni -- 39. Governmental support of research / Sten H. Vermund and Salim Abdool Karim -- 40. The role of nonprofit, non-governmental funding in support of biomedical research / Rose Marie Robertson and Suzie Upton -- 41. Modern drug discovery and development / Daniel E. Salazar and Glenn Gormley -- 42. Pharmaceutical and biotechnology sector support of research / Joann Data -- Section X Prospectus -- 43. The future of clinical research / Gordon H. Williams and David Robertson.