000			05388cam a22002777i 4500
001			19757291
008			170624s2017 ne a b 001 0 eng c
020			_a9780128021019 (paperback)
020			_a0128021012
040			_aPGIML _beng
060			_aW20.5 _bC43 _2
130	0		_aClinical and translational science (Robertson)
245	1	0	_aClinical and translational science : _bprinciples of human research / _cedited by David Robertson, MD, Director, Clinical & Translational Research Center, Elton yates Professor of Medicine, Pharmacology and Neurology, Vanderbilt University, Nashville, TN, United States ; Gordon H. Williams, MD, Chief, Hormonal Mechanisms of Cardiovascular Injury Laboratory, Brigham and Women's Hospital, and Professor of Medicine, Harvard Medical School, Boston, MA, United States.
250			_aSecond edition.
260			_aUnited Kingdom: _bElsevier; _c2017.
300			_axx, 788 pages : _billustrations ; e-Book _c28 cm
504			_aIncludes bibliographical references and index.
505	0		_aSection I Fundamental Principles -- 1. Introduction to clinical research / Gordon H. Williams and David Robertson -- 2. Patient-oriented research / Ellen W. Seely and Steven Grinspoon -- 3. Clinical trials / Robert M. Califf -- 4. Introduction to epidemiology / Donna K. Arnett and Steven A. Claas -- 5. The patient-centered outcomes research institute / Joe V. Selby and Danielle M. Whicher -- 6. Health-care technology assessment (HTA) / Uwe E. Reinhardt -- 7. Health services research / J. Sanford Schwartz -- Section II Approaches -- 8. Measurement of biological materials / Mark D. Kellogg -- 9. Imaging tools in clinical research / Ruth M. Dunne, Alibhe C. O'Neill and Clare M. Tempany -- 10. Imaging tools in human research / Ruth M. Dunne, Alibhe C. O'Neill and Clare M. Tempany -- 11. Nanotechnology in clinical and translational research / James B. Baker Jr., Brent B. Ward and Thommey P. Thomas -- 12. The use of questionnaires and surveys / Marcia A. Testa and Donald C. Simonson -- 13. Informational technology / Shawn N. Murphy, Henry C. Chueh and Christopher D. Herrick -- 14. Principles of biostatistics / Kush Kapur -- 15. Good clinical practice and good laboratory practice / Nathalie K. Zgheib, Stephanie L. Tomasic and Robert A. Branch -- Section III Human Genetics -- Introduction to human genetics / Bruce R. Korf -- 17. Epidemiologic and population genetic studies / Angela J. Rogers and Scott T. Weiss -- 18. Pharmacogenetics of drug metabolism / Zerusenay Desta and David A. Flockhart -- 19. Statistical techniques for genetic analysis / Jessica Lasky-Su -- Section IV Human Pharmacology -- 20. Introduction to clinical pharmacology / Rommel G. Tirona and Richard B. Kim -- 21. Adverse drug events / Dan M. Roden -- Section V Societal Context of Human Research -- 22. Translating science to the bedside / Seema Basu -- 23. Regulatory environment / Christine Nguyen, Audrey Gassman and Hylton V. Joffe -- 24. Ethical issues in translational research and clinical investigation / Greg Koski -- 25. Clinical research in the public eye / Mary Wooley -- Section VI Research in Special Populations -- 26. Research in special populations / Todd W. Rice and Gordon R. Bernard -- 27. Research in the emergency care environment / James Quinn and Daniel J. Pallin -- 28. Psychiatric disorders / Alan F. Schatzberg -- 29. Research in special populations / Stephanie Studenski and Luigi Ferrucci -- 30. Clinical research in neurology / Keren Regev and Howard L. Weiner -- 31. Research in pediatrics / Lisa Bomgaars, Stacey Berg and Ann R. Stark -- 32. Cancer as a paradigm for translational and clinical biomedical research / César Serrano and George D. Demetri -- 33. Maintaining an emphasis on rare diseases with research initiatives and resources at the national center for advancing translational sciences / Stephen C. Groft and Rashmi Gopal-Srivastava -- Section VII Infrastructure -- 34. Clinical and Translational Science Infrastructure / David Robertson and Gordon H. Williams -- Section VIII Education, Training and Career Choices -- 35. Education, Training and Career Choices / Katherine E. Hartmann, Elizabeth Heitman and Nancy J. Brown -- A stepwise approach to a career in translational research / William F. Crowley Jr. -- Physician careers in the pharmaceutical industry / Ronald L. Krall -- Section IX Research in Academia -- 38. Industry-sponsored clinical research in academia / Italo Biaggioni -- 39. Governmental support of research / Sten H. Vermund and Salim Abdool Karim -- 40. The role of nonprofit, non-governmental funding in support of biomedical research / Rose Marie Robertson and Suzie Upton -- 41. Modern drug discovery and development / Daniel E. Salazar and Glenn Gormley -- 42. Pharmaceutical and biotechnology sector support of research / Joann Data -- Section X Prospectus -- 43. The future of clinical research / Gordon H. Williams and David Robertson.
650		0	_aGeneral Medicine, Health Professions _xBiomedical Research _xMedicine, Experimental _xClinical medicine--Research _xGenetic Research. _xClinical Medicine. _93090
700			_aRobertson, D. _d1947- _eeditor. _95564
700			_aWilliams, G.H. _eeditor. _95565
906			_a7 _bcbc _cpccadap _d2 _encip _f20 _gy-gencatlg
942			_2lcc _cBK
999			_c5238 _d5238